Case report Roberto Nevarez Bernal, Pablo Vilchis Nava , Alberto Kably Ambe Ginecol Obstet Mex 2007, 75:168-71 Level of evidence: III Specialized Center for the Care of Women. Director of the Center for Assisted Reproduction, Specialized Center for the Care of Women. Hospital Angeles Lomas, Huixquilucan, Mexico. Correspondence: Dr. Roberto Nevarez Bernal. Specialized Center for the Care of Women. Hospital Angeles Lomas. Roads de la Barranca s / n, Colonia Valle de las Palmas, CP 52,763, Huixquilucan, Mexico State, Mexico. ABSTRACT Endometrial ossification is a rare reproductive condition, predisposing factors include a history of curettage uterine and metabolic diseases. This condition is common in women with secondary infertility and a history of loss gestation in the first trimester of pregnancy. The patients manifested disabling dysmenorrhea and dyspareunia. The diagnosis is done with the prior gynecoobstetrical and ultrasound findings. Treatment strategies involve curettage instrumented and hysterectomy. The diagnosis and treatment of choice is through hysteroscopic to preserve future fertility endometrial and minimize harm. It communicates the review of four cases occurring from 1985 to 2004. Keywords: uterine diseases, endometrial ossification. ABSTRACT Endometrial ossification is a rare endometrial pathology.Its predisposing factors include history of uterine curettage to metabolic abnormalities. It usually presents in patients with secondary infertility and history of first trimester pregnancy loss, Accompanied by severe dysmenorrhea and dyspareunia. The diagnosis is suspected by history and OB-GYN USG findings, therapeutic strategies range from D C to hysterectomy, we propose diagnosis and management by hysteroscopy in order to preserve future fertility and uterine minimize damage. A review of four cases during 1985-2004 from a large assisted reproduction center in Mexico City is presented. Key Words: Uterine diseases, endometrial ossification. . Received: November, 2006. Accepted: February, 2007. This article should be cited as: Nevarez BR, Vilchis NP, Kabli AA. Endometrial ossification: Report of four cases and review acknowledged. Ginecol Obstet Mex 2007, 75:168-71. Endometrial ossification is a condition reproductive extremely origin surprising, since until 2001 it was reported only 60 cases worldwide.1 The predisposing factors include: History of instrumented curettage. Chronic Endometriosis. Metabolic diseases (hypervitaminosis D, hypercalcemia, hyperparathyroidism, hyperphosphatemia). estrogen stimulation without oposici n.1-4 Endometrial ossification is common in patients with infertility and repeated abortions, such cases are characterized by menstrual irregularity, dysmenorrhoea and dispareunia.3, 5 treatment strategies consists of curettage and hysterectomy total abdominal.Nowadays, hysteroscopy is considered suitable for demonstrating good advantages m nima.2 invasive surgery, 3 CASE 1 Patient 29 years of age, secondary infertility six years of evolution, history heredofamiliares personal and unimportant. In obstetric history indicated menstrual cycles regular and a previous pregnancy (six years) a loss in the first quarter. Was performed instrumented curettage without complications. Began tracking secondary infertility found no causal factors in laparoscopic study minimal endometriosis were identified. After this test was performed curettage instrumented and uterine biopsy in the report histopathology was observed bone tissue and endometrium secretor.